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Comorbidity of gout and rheumatoid arthritis in a large population database

Rona Merdler-Rabinowicz1,2, Shmuel Tiosano1,2, Doron Comaneshter3

  • 1Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, 52621, Tel Hashomer, Israel.

Clinical Rheumatology
|November 13, 2016
PubMed

Insights

Rheumatoid arthritis patients have a higher prevalence of gout than previously thought. This study found rheumatoid arthritis is significantly associated with gout, challenging the notion of their rare coexistence.

Area of Science:

  • Rheumatology
  • Epidemiology

Background:

  • The coexistence of rheumatoid arthritis and gout is often considered uncommon.
  • Existing literature suggests a low prevalence of gout among rheumatoid arthritis patients.

Purpose of the Study:

  • To investigate the prevalence of gout in patients diagnosed with rheumatoid arthritis.
  • To compare the incidence of gout in rheumatoid arthritis patients versus the general population.

Main Methods:

  • A population-based cross-sectional study was conducted using data from Clalit Health Services.
  • 11,540 rheumatoid arthritis patients were compared with 56,763 age- and sex-matched controls.
  • Data included BMI, socioeconomic status, smoking, hypertension, and gout diagnosis.

Main Results:

  • The prevalence of gout was significantly higher in rheumatoid arthritis patients (1.61%) compared to controls (0.92%).
  • Multivariate analysis revealed a significant association between rheumatoid arthritis and gout (OR = 1.72).
  • The proportion of gout in rheumatoid arthritis patients was not lower than in the general population.

Conclusions:

  • The coexistence of rheumatoid arthritis and gout is more common than previously believed.
  • Rheumatoid arthritis is independently associated with an increased risk of developing gout.
  • Findings suggest a potential shared pathophysiology or increased susceptibility to crystal deposition in rheumatoid arthritis patients.

Keywords:
ComorbidityCrystal induced arthritisGoutInflammationRheumatic diseasesRheumatoid arthritis

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