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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
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Systemic Antifungal Agents: Current Status and Projected Future Developments.
Seyedmojtaba Seyedmousavi1,2, Haleh Rafati3, Macit Ilkit4
1Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands. S.Seyedmousavi@gmail.com.
Methods in Molecular Biology (Clifton, N.J.)
|November 13, 2016
Summary
Limited antifungal drugs exist for rising fungal infections. This review covers current systemic antifungal agents and highlights new drug development for invasive fungal infections, addressing unmet clinical needs.
Area of Science:
- Medical Science
- Pharmacology
Background:
- Fungal infections are increasing, especially in immunocompromised individuals.
- Current antifungal drugs (polyenes, azoles, echinocandins, nucleoside analogs) have limited efficacy for life-threatening infections.
Purpose of the Study:
- To review currently available systemic antifungal drugs.
- To discuss unmet needs and emerging antifungal therapies for invasive fungal infections.
Main Methods:
- Literature review of systemic antifungal drug classes.
- Discussion of drug reformulation and novel agent development.
Main Results:
- Overview of established antifungal drug classes and their limitations.
- Identification of new antifungal agents targeting known and novel pathways.
Conclusions:
- There is a critical need for novel antifungal agents with improved efficacy.
- Ongoing research focuses on reformulating existing drugs and developing new agents with novel mechanisms to combat invasive fungal infections.
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