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Updated: Mar 12, 2026

Formulation and Characterization of Bioactive Agent Containing Nanodisks
Published on: March 17, 2023
Stable Discoidal Bicelles: A Platform of Lipid Nanocarriers for Cellular Delivery
Ying Liu1, Yan Xia1, Armin Tahmasbi Rad2
1Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Abstract:
Bicellar mixtures have been used as alignable membrane substrates for the structural characterization of membrane-associated proteins. Most recently, it has been shown that bicelles can serve as nanocarriers to effectively deliver hydrophobic molecules to cancer cells with a 3- to 10-fold enhancement compared to that of chemically identical liposomes. In this chapter, a detailed preparation protocol, common structural characterization methods, the structural stability and the cellular uptake of bicellar nanodisks are discussed.

