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An unknown compound can be established by identifying the molecular ion peak in the mass spectrum. The molecular ion peak is often weak or absent due to the predominance of fragmentation in high-energy electron beams. In such cases, a soft-energy electron beam can be used to scan the spectrum to enhance the intensity of the molecular ion peak. Additionally, chemical ionization, field ionization, and desorption ionization spectra are used to obtain a relatively intense molecular ion peak.To...
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The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
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Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
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Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
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Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
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X-ray ionization differential ion mobility spectrometry.

Andriy Kuklya1, Tobias Reinecke2, Florian Uteschil1

  • 1Department of Instrumental Analytical Chemistry, University of Duisburg-Essen (UDE), Universitätsstraße 5, 45141 Essen, Germany.

Talanta
|November 14, 2016
PubMed
Summary
This summary is machine-generated.

X-ray ionization is a novel, nonradioactive method for differential ion mobility spectrometry (DMS). This technique shows comparable analytical performance to traditional radioactive sources, enhancing DMS for on-site applications.

Keywords:
(63)Ni ionizationChemical ionization (CI)Differential ion mobility spectrometry (DMS)High field asymmetric waveform ion mobility spectrometry (FAIMS)On-site monitoringX-ray ionization

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Area of Science:

  • Analytical Chemistry
  • Spectrometry
  • Ionization Techniques

Background:

  • Differential Ion Mobility Spectrometry (DMS) traditionally uses radioactive ionization sources like 63Ni.
  • Developing nonradioactive ionization sources is crucial for expanding DMS applications, especially for on-site use.

Purpose of the Study:

  • To investigate X-ray as a novel, nonradioactive ionization source for DMS.
  • To evaluate the influence of experimental parameters on X-ray ionization in DMS.
  • To compare the analytical performance of X-ray ionization with a traditional 63Ni source.

Main Methods:

  • Utilized X-ray as an ionization source for DMS for the first time.
  • Investigated the effect of accelerating voltage and filament current on reactive ion peaks (RIPs).
  • Determined analytical performance, including Limit of Detection (LOD), for model compounds (acetone, methyl salicylate).

Main Results:

  • X-ray ionization produced RIPs identical to the 63Ni source, particularly in negative ion mode.
  • Increased filament current and accelerating voltage enhanced RIP intensity.
  • Achieved LOD values (0.17-1.52 ppbv/v) competitive with the 63Ni ionization source.

Conclusions:

  • X-ray ionization is a viable nonradioactive alternative for DMS.
  • This method holds significant potential for developing portable, on-site DMS systems.
  • Further optimization of X-ray adapters could enhance performance.