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Updated: Aug 18, 2026

A 96 Well Microtiter Plate-based Method for Monitoring Formation and Antifungal Susceptibility Testing of Candida albicans Biofilms
Published on: October 21, 2010
Exploring the anti-biofilm activity of cinnamic acid derivatives in Candida albicans
Daniela De Vita1, Giovanna Simonetti2, Fabiana Pandolfi1
1Department of Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro, 5, I-00185 Rome, Italy.
Abstract:
Some compounds, characterized by phenylethenyl moiety, such as methyl cinnamate and caffeic acid phenethyl ester, are able to inhibit C. albicans biofilm formation. On these bases, and as a consequence of our previous work, we synthesized a series of cinnamoyl ester and amide derivatives in order to evaluate them for the activity against C. albicans biofilm and planktonically grown cells. The most active compounds 7 and 8 showed ⩾50% biofilm inhibition concentrations (BMIC50) of 2μg/mL and 4μg/mL respectively, against C. albicans biofilm formation; otherwise, 7 showed an interesting activity also against mature biofilm, with BMIC50 of 8μg/mL.
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