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[The relationship between metabolic disorders and small for gestational age with idiopathic premature adrenarche]

Francisco Javier Mejorado Molano1, Laura Andrés Zallo2, Marta Fornos Rodríguez2

  • 1Servicio de Pediatría, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, España.

Anales De Pediatria (Barcelona, Spain : 2003)
|November 14, 2016
PubMed

Insights

Idiopathic premature adrenarche (IPA) in girls is not linked to being small for gestational age. Overweight and obesity rates in IPA girls are similar to the general population.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Health
  • Adolescent Health

Background:

  • Controversy exists regarding the association between idiopathic premature adrenarche (IPA) and small for gestational age (SGA) history.
  • The co-occurrence of obesity and metabolic disturbances in girls with IPA requires further investigation.

Purpose of the Study:

  • To investigate the relationship between IPA and SGA history in a cohort of girls.
  • To assess the prevalence of overweight, obesity, and metabolic disturbances in girls diagnosed with IPA.

Main Methods:

  • A descriptive cross-sectional study included 76 girls diagnosed with IPA between 2007 and 2015.
  • Data collected included family/personal history, perinatal details, anthropometry, and biochemical values at diagnosis.

Main Results:

  • 2.7% of IPA girls had a history of SGA; this is not higher than the general population.
  • Prevalence of overweight and obesity in IPA girls was comparable to the general population.
  • Insulin resistance (21.2%) and dyslipidemia (13.95%) were observed, with overweight/obese IPA girls showing higher triglycerides, insulin, and HOMA index, and lower HDL cholesterol.

Conclusions:

  • IPA in girls is not associated with a higher prevalence of SGA.
  • The prevalence of overweight and obesity in girls with IPA is similar to that of the general population, but metabolic disturbances like insulin resistance and dyslipidemia are present.
Abstract

Keywords:
Adrenarquia prematura idiopáticaIdiopathic premature adrenarcheObesidad y pequeño para edad gestacionalObesity and small for gestational ageOverweightSobrepeso

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