Metronomic chemotherapy and nanocarrier platforms
Amr S Abu Lila1, Tatsuhiro Ishida2
1Department of Pharmacokinetics and Biopharmaceutics, Institute of Medical Biosciences, Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Hail University, Hail 2440, Saudi Arabia.
Cancer Letters
|November 14, 2016
Summary
Metronomic chemotherapy, a low-dose continuous regimen, shows promise for anti-angiogenic cancer therapy with reduced toxicity. Combining it with nanocarrier drug delivery enhances therapeutic outcomes, improving cancer treatment efficacy.
Area of Science:
- Oncology
- Nanotechnology
- Pharmacology
Background:
- Metronomic chemotherapy involves continuous low-dose chemotherapy, offering reduced toxicity compared to maximum tolerated dose (MTD) regimens.
- While promising for anti-angiogenic cancer therapy, metronomic chemotherapy has shown limited success as a monotherapy in clinical trials.
- Combining metronomic chemotherapy with conventional therapies or nanocarrier-based drug delivery systems can potentiate therapeutic outcomes.
Purpose of the Study:
- To review the role of nanoscale drug delivery platforms in enhancing the efficacy of metronomic chemotherapy.
- To discuss the impact of dosing schedules on the overall therapeutic effectiveness of metronomic chemotherapy.
Main Methods:
- Literature review focusing on the synergistic effects of nanocarrier drug delivery and metronomic chemotherapy.
- Analysis of studies investigating the influence of dosing schedules on metronomic chemotherapy efficacy.
Main Results:
- Nanoscale drug delivery platforms significantly enhance the therapeutic efficacy of metronomic chemotherapy by enabling targeted delivery and controlled release of agents.
- Combinations of metronomic chemotherapy with nanomedicine and conventional treatments show improved anti-cancer effects.
- Optimized dosing schedules are crucial for maximizing the benefits of metronomic chemotherapy.
Conclusions:
- Nanoscale drug delivery systems are vital for improving metronomic chemotherapy's clinical success.
- Further research into optimized dosing strategies and nanocarrier formulations is warranted to fully exploit metronomic chemotherapy's potential.
- The combination of metronomic chemotherapy with nanomedicine represents a promising strategy for advanced cancer treatment.
Related Concept Videos
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
79
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
79
01:24Modified-Release Drug Delivery Systems: Site-Targeted
70
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
70
02:57Targeted Cancer Therapies
9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.1K
02:57Targeted Cancer Therapies
1.7K
1.7K
02:50Combination Therapies and Personalized Medicine
6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K
02:49Cancer Therapies
10.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.5K