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Vaccinations

Vaccinations

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Related Experiment Video

Updated: Mar 12, 2026

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

Forecasting Epidemiological Consequences of Maternal Immunization.

Ana I Bento^1,2, Pejman Rohani^1,2,3

¹Odum School of Ecology.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America

|November 14, 2016

Summary

Maternal immunization effectively reduces infant whooping cough (pertussis) incidence. However, potential antibody interference may increase disease in older children over time.

Keywords:

blunting interference maternal immunization pertussis routine vaccination

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Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

Area of Science:

Epidemiology
Immunology
Mathematical Modeling

Background:

Rising whooping cough (pertussis) incidence in vaccinated populations is a public health concern.
Maternal pertussis immunization is explored to protect newborns before routine vaccination.
Concerns exist about maternal antibodies interfering with infant immune responses and long-term effects.

Purpose of the Study:

To model the long-term epidemiological impact of maternal and routine pertussis immunization.
To assess the consequences of potential immune interference between maternal antibodies and routine vaccination.

Main Methods:

Development of a mathematical transmission model incorporating both routine and maternal immunization strategies.
Simulation of various immune interference scenarios to evaluate population-level effects.

Main Results:

Maternal immunization significantly reduces pertussis incidence in neonates.
Model predicts a 43% decrease in neonatal incidence with 60% coverage and 30% antibody blunting.
A 20% increase in incidence among 5-10 year olds is predicted under the same conditions, with a delayed onset of over a decade.

Conclusions:

Maternal immunization offers substantial benefits in reducing infant pertussis burden.
Adverse effects of maternal antibodies on routine vaccine immunogenicity could lead to increased incidence in older age groups over the long term.