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Altered Motor-Striatal Plasticity and Cortical Functioning in Patients with Schizophrenia
Dongsheng Zhou1, Feng Pang2, Shiyan Liu1
1Ningbo Kangning Hospital, Ningbo Key Laboratory of Behavioral Neuroscience, Ningbo, 315201, China.
Abstract:
Patients with schizophrenia undergo changes in brain plasticity. In the present study, we characterized motor cortical-striatal plasticity in such patients. Compared with the potentiation following high-frequency repetitive transcranial magnetic stimulation in the control group, the patients demonstrated impaired plasticity of corticostriatal motor-evoked potentials recorded from hand muscles. Notably, the loss of cortical plasticity was correlated with impaired motor learning in a rotary pursuit task. Moreover, the loss of plasticity was correlated with the symptoms of schizophrenia. The results suggest that the progression of schizophrenia is accompanied by altered cortical plasticity and functioning.
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