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Related Experiment Videos

CCN3: stopping that achy, breaky aorta.

Andrew Leask1

  • 1Departments of Dentistry and Physiology and Pharmacology, University of Western Ontario, Dental Sciences Building, London, ON, N6A 5C1, Canada. Andrew.leask@schulich.uwo.ca.

Journal of Cell Communication and Signaling
|November 14, 2016
PubMed
Summary

Abdominal aortic aneurysm (AAA) is a serious condition affecting older men. Research suggests CCN3 may offer a potential new treatment for AAA.

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Area of Science:

  • Vascular Biology
  • Molecular Medicine

Background:

  • Abdominal aortic aneurysm (AAA) impacts 2-8% of males over 65.
  • Ruptured AAA carries a high mortality rate of 85-90%.

Purpose of the Study:

  • To summarize recent findings on the potential therapeutic role of CCN3 in treating AAA.

Main Methods:

  • Review of data from Zhang and colleagues (J Clin Invest 126(4):1282-1299 2016).

Main Results:

  • Recent research indicates CCN3 as a potential therapeutic agent for AAA.

Conclusions:

  • CCN3 shows promise as a novel treatment strategy for abdominal aortic aneurysms.
Keywords:
Abdominal aortic aneurysmCCN familyCCN3Cardiovascular diseaseMatricellular proteinsNov