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Published on: January 13, 2017
A new spectinabilin derivative with cytotoxic activity from ant-derived Streptomyces sp. 1H-GS5
Chong-Xi Liu1, Shuang-He Liu1,2, Jun-Wei Zhao1
1a Life Science and Biotechnology Research Center , School of Life Science, Northeast Agricultural University , Harbin 150030 , China.
Abstract:
A new spectinabilin derivative (1) was isolated from the fermentation broth of the ant-derived Streptomyces sp. 1H-GS5, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed cytotoxicity against human tumor cell lines A549, HCT-116, and HepG2 with IC50 values of 9.7, 12.8, and 9.1 μg/ml, respectively, which was relative higher than that of spectinabilin.

