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CDH13 gene-by-PM10 interaction effect on lung function decline in Korean men
Hyun-Jin Kim1, Jin-Young Min1, Kyoung-Bok Min2
1Institute of Health and Environment, Seoul National University, Seoul 08826, South Korea.
Chemosphere
|November 15, 2016
Summary
Genetic variants in the Cadherin 13 (CDH13) gene can alter how particulate matter (PM10) affects lung function. Specific CDH13 variants increase susceptibility to PM10-induced lung function decline in Korean men.
Area of Science:
- Environmental Health
- Genetics
- Pulmonary Medicine
Background:
- Individual susceptibility to air pollution varies due to genetic factors.
- Particulate matter (PM10) exposure is a known risk factor for reduced lung function.
Purpose of the Study:
- To investigate the interaction between Cadherin 13 (CDH13) gene variants and PM10 exposure on lung function in Korean men.
- To identify specific CDH13 single-nucleotide polymorphisms (SNPs) that modify the effects of PM10 on lung function.
Main Methods:
- A study involving 1827 Korean men.
- Analysis of 200 CDH13 gene SNPs and annual average PM10 concentrations.
- Interaction analysis using a recessive model for a specific SNP (rs1862830).
Main Results:
- A significant interaction between PM10 and CDH13 SNP rs1862830 on lung function (FEV1 and FVC) was identified.
- Homozygous risk-allele carriers (AA) of rs1862830 showed significant decreases in FEV1 (3.8%) and FVC (3.1%) per 10 μg/m³ increase in PM10.
- These findings were consistent across independent subgroups.
Conclusions:
- The CDH13 gene, specifically variant rs1862830, modifies the impact of PM10 on lung function in Korean men.
- Genetic variations in CDH13 play a role in individual susceptibility to air pollution-related lung function decline.
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