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Published on: February 6, 2021
Propionibacterium-associated endophthalmitis after extracapsular cataract extraction. Review of reported cases
1Department of Ophthalmology, Cleveland Clinic Foundation, OH 44106.
Abstract:
Sixteen cases of previously reported culture-proven Propionibacterium-associated endophthalmitis after extracapsular cataract extraction (ECCE) are reviewed. The inflammation was observed 2 to 10 months after surgery and occurred after laser posterior capsulotomy in four cases. Clinically, it appeared as a chronic iridocyclitis characterized by granulomatous-appearing keratic precipitates (5 cases), hypopyon (10 cases), and a white plaque on the posterior capsule or intraocular lens (IOL) implant (8 cases). Response to corticosteroid treatment was transient. Surgical intervention was required between 1 and 16 months after the inflammation began and included removal of the IOL and capsular bag via the limbus in 7 cases and pars plana vitrectomy in 11. Intravitreal antibiotics were administered in 12 cases. Postoperative visual acuity ranged from 20/20 to count fingers, with 11 of 16 patients recovering visual acuity of 20/40 or better. Propionibacterium-associated endophthalmitis should be suspected if chronic indolent intraocular inflammation develops after ECCE. Intraocular specimens should be obtained and submitted for aerobic and anaerobic culture and cytologic/histopathologic studies. Based on the clinical courses of these patients, recommendations for management are discussed.
Insights
Propionibacterium endophthalmitis is a rare complication following cataract surgery. Early suspicion and appropriate diagnostic workup are crucial for managing this indolent intraocular inflammation.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Surgical Complications
Background:
- Propionibacterium endophthalmitis is a significant complication after extracapsular cataract extraction (ECCE).
- This condition often presents as a chronic, indolent intraocular inflammation, typically months after initial surgery.
Purpose of the Study:
- To review cases of Propionibacterium-associated endophthalmitis following ECCE.
- To discuss the clinical presentation, management, and outcomes of this specific type of endophthalmitis.
Main Methods:
- Retrospective review of sixteen culture-proven cases of Propionibacterium endophthalmitis.
- Analysis of clinical presentation, time of onset, treatment interventions, and visual acuity outcomes.
Main Results:
- Inflammation occurred 2-10 months post-ECCE, sometimes after laser posterior capsulotomy.
- Clinical signs included chronic iridocyclitis, keratic precipitates, hypopyon, and posterior capsule plaques.
- Surgical intervention and intravitreal antibiotics were common; 11/16 patients achieved visual acuity of 20/40 or better.
Conclusions:
- Propionibacterium endophthalmitis should be suspected in cases of chronic intraocular inflammation post-ECCE.
- Prompt diagnosis via intraocular specimen culture and appropriate management, including surgical intervention and antibiotics, are vital for visual recovery.
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