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Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1

Deepankar Gahloth1, Colin Levy1, Graham Heaven2

  • 1School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK.

Structure (London, England : 1993)
|November 15, 2016
PubMed
Summary

The tumor suppressor HD-PTP regulates receptor degradation via ESCRT pathways. Structural studies reveal its unique coiled-coil domain interaction with UBAP1, offering insights for cancer therapies.

Keywords:
coiled-coil structureendosomal ESCRTs regulationmitogenic signaling downregulationtumor suppressor phosphataseubiquitin-dependent trafficking

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