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Updated: Mar 12, 2026

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia
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CD98 signals controlling tumorigenesis.

Hugh Ip1, Tariq Sethi2

  • 1Guy's and St Thomas' NHS Foundation Trust, United Kingdom.

The International Journal of Biochemistry & Cell Biology
|November 15, 2016
PubMed
Summary
This summary is machine-generated.

CD98 regulates amino acid transport and integrin signaling, crucial for cancer progression. Blocking CD98 offers potential new cancer therapeutics by targeting these key drivers.

Keywords:
Amino acid transportCD98;CancerIntegrinsSignalling

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Area of Science:

  • Oncology and Molecular Biology: Focuses on the role of CD98 in cancer.

Background:

  • CD98 (also known as SLC3A2) is implicated in numerous cancers.
  • It regulates critical processes like amino acid transport and integrin signaling, which drive tumor progression.
  • The CD98 heterodimer, composed of a heavy and a light chain, mediates these functions at the plasma membrane.

Purpose of the Study:

  • To review current therapeutic strategies targeting CD98.
  • To explore the potential of blocking CD98 activity for novel cancer treatments.

Main Methods:

  • Literature review of studies investigating CD98 function in cancer.
  • Analysis of various approaches to inhibit CD98 activity.

Main Results:

  • CD98's light chain acts as an amino acid exchanger.
  • The heavy chain, in conjunction with the light chain, forms a heterocomplex involved in signaling pathways.
  • Dysregulation of these pathways contributes to cancer development and progression.

Conclusions:

  • Targeting CD98 presents a promising avenue for developing new cancer therapeutics.
  • Inhibiting CD98 activity may disrupt key mechanisms of tumor growth and survival.