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Polysaccharide-coated liposomal formulations for dental targeting
Sara Pistone1, Morten Rykke2, Gro Smistad1
1SiteDel Group, School of Pharmacy, University of Oslo, P. O. Box 1068, Blindern, 0316 Oslo, Norway.
International Journal of Pharmaceutics
|November 15, 2016
Summary
Negatively charged liposomes demonstrated superior stability in artificial saliva and show promise as tooth-adhesive nanosystems. This research offers potential for improved oral ailment treatments through enhanced bioadhesive formulations.
Area of Science:
- Oral drug delivery
- Materials science
- Nanotechnology
Background:
- Conventional oral treatments suffer from low residence time, limiting efficacy.
- Bioadhesive formulations offer a potential solution to prolong drug contact in the oral cavity.
- Liposomes are versatile nanocarriers for drug delivery applications.
Purpose of the Study:
- To investigate charged liposomes, coated with polysaccharides, as bioadhesive systems for oral applications.
- To evaluate the stability of these liposomes in artificial saliva.
- To assess the bioadhesive properties of liposomes on hydroxyapatite.
Main Methods:
- Preparation and characterization of uncoated and polysaccharide-coated (chitosan, alginate, pectin) liposomes.
- In vitro stability testing of liposomes in artificial saliva.
- Adsorption studies of liposomes onto hydroxyapatite, a model for tooth enamel.
Main Results:
- Liposome surface charge significantly influenced stability and bioadhesion.
- Negatively charged liposomes exhibited the highest stability in artificial saliva.
- Positively charged liposomes showed the greatest bioadhesion to hydroxyapatite, while negatively charged liposomes had moderate adsorption.
Conclusions:
- Negatively charged liposomes are the most stable in simulated salivary conditions.
- Polysaccharide coating improved the stability of positively charged liposomes.
- Negatively charged liposomes represent a promising tooth-adhesive nanosystem for enhanced oral ailment treatments.
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