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Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
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Microbial genome-wide association studies: lessons from human GWAS
Robert A Power1, Julian Parkhill2, Tulio de Oliveira1,2,3
1Africa Centre for Population Health, Nelson R. Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa.
Nature Reviews. Genetics
|November 15, 2016
Summary
Microbial genome-wide association studies (GWAS) leverage whole-genome sequencing to understand infectious diseases, antibiotic resistance, and transmission. Lessons from human GWAS will guide future microbial research.
Area of Science:
- Microbiology
- Genomics
- Epidemiology
Background:
- Decreased sequencing costs enable whole-genome analysis for numerous microorganisms.
- Microbial genome-wide association studies (GWAS) are emerging as powerful tools.
- Human GWAS have successfully elucidated disease etiology and identified drug targets.
Purpose of the Study:
- To review microbial genome-wide association study (GWAS) methodologies.
- To summarize the current landscape of microbial GWAS.
- To explore how human GWAS insights can shape the future of microbial GWAS.
Main Methods:
- Review of existing literature on microbial and human GWAS.
- Analysis of methodologies employed in microbial GWAS.
- Comparative study of human and microbial GWAS approaches.
Main Results:
- Microbial GWAS offer significant potential for understanding infectious diseases.
- Applications include insights into antibiotic resistance and disease transmission.
- The field is rapidly advancing, drawing parallels with human GWAS successes.
Conclusions:
- Microbial GWAS are poised to revolutionize the study of infectious diseases.
- Translating human GWAS strategies can accelerate progress in microbial research.
- Future research should focus on refining GWAS methodologies for microbial applications.
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