Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

1.8K
The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
1.8K
Mass Analyzers: Overview01:13

Mass Analyzers: Overview

2.0K
The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
2.0K
Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

2.8K
Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An X-ray fluorescence method for direct-on-filter quantification of airborne particulate metals using a handheld analyzer.

Analytical methods : advancing methods and applications·2026
Same author

Isolated Hepatic Cryptococcosis in an Immunocompetent Child: A Rare Cause of Granulomatous Hepatitis with Cholestasis.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026
Same author

Tandem Raman and Elemental Aerosol Spectrometer (TREAS) for Near-Real-Time Aerosol Chemical Speciation.

Analytical chemistry·2026
Same author

Flow imaging microscopy-based method for rapid, high-throughput measurement of fiber count and length distributions in air.

Environmental science. Processes & impacts·2025
Same author

Pulmonary inflammatory and fibrogenic responses in rats following intratracheal instillation of dusts from natural and engineered stones.

Journal of toxicology and environmental health. Part A·2025
Same author

Differentiating the in vitro toxicity of solid-surface composite dust: A comparison of material components and abrasive particles.

Toxicology letters·2025

Related Experiment Video

Updated: Mar 12, 2026

Measuring Sub-23 Nanometer Real Driving Particle Number Emissions Using the Portable DownToTen Sampling System
08:59

Measuring Sub-23 Nanometer Real Driving Particle Number Emissions Using the Portable DownToTen Sampling System

Published on: May 22, 2020

6.0K

Miniature Differential Mobility Analyzer for Compact Field-Portable Spectrometers.

Chaolong Qi1, Pramod Kulkarni1

  • 1Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1090 Tusculum Ave, MS: R7, Cincinnati, OH, 45226.

Aerosol Science and Technology : the Journal of the American Association for Aerosol Research
|November 15, 2016
PubMed
Summary

A new miniature differential mobility analyzer (mDMA) enables portable aerosol spectrometers. This compact device accurately classifies submicrometer particles for field measurements.

More Related Videos

All-electronic Nanosecond-resolved Scanning Tunneling Microscopy: Facilitating the Investigation of Single Dopant Charge Dynamics
11:33

All-electronic Nanosecond-resolved Scanning Tunneling Microscopy: Facilitating the Investigation of Single Dopant Charge Dynamics

Published on: January 19, 2018

10.3K
Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
08:40

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

Published on: January 20, 2022

4.9K

Related Experiment Videos

Last Updated: Mar 12, 2026

Measuring Sub-23 Nanometer Real Driving Particle Number Emissions Using the Portable DownToTen Sampling System
08:59

Measuring Sub-23 Nanometer Real Driving Particle Number Emissions Using the Portable DownToTen Sampling System

Published on: May 22, 2020

6.0K
All-electronic Nanosecond-resolved Scanning Tunneling Microscopy: Facilitating the Investigation of Single Dopant Charge Dynamics
11:33

All-electronic Nanosecond-resolved Scanning Tunneling Microscopy: Facilitating the Investigation of Single Dopant Charge Dynamics

Published on: January 19, 2018

10.3K
Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments
08:40

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

Published on: January 20, 2022

4.9K

Area of Science:

  • Aerosol Science and Technology
  • Instrument Development
  • Nanoparticle Characterization

Background:

  • Accurate measurement of submicrometer aerosol size distribution is crucial for environmental and health studies.
  • Existing differential mobility analyzers (DMAs) can be bulky, limiting their use in field applications.
  • Development of compact, portable instrumentation is needed for on-site aerosol analysis.

Purpose of the Study:

  • To develop and evaluate a low-flow miniature differential mobility analyzer (mDMA) for compact, field-portable aerosol spectrometers.
  • To assess the performance characteristics, including size range, resolution, and transmission efficiency, of the novel mDMA.
  • To demonstrate the suitability of the mDMA for classifying submicrometer and nanoparticles in real-world conditions.

Main Methods:

  • Design and fabrication of a miniature differential mobility analyzer (mDMA) with an ultra-low aerosol flow rate.
  • Characterization of the mDMA's performance using tandem DMA (TDMA) measurements.
  • Modeling of the mDMA's transfer function using Stolzenburg's model and comparison with experimental data.
  • Evaluation of transmission efficiency and mobility resolution against established DMA systems.

Main Results:

  • The mDMA was successfully designed with dimensions suitable for compact spectrometers and operates at an ultra-low aerosol flow rate (0.05 L/min).
  • Experimental transfer functions closely matched theoretical predictions based on Stolzenburg's model.
  • The mDMA demonstrated comparable transmission efficiency to the Knutson-Whitby DMA for particles between 10-1000 nm.
  • Mobility resolution was found to be comparable to the TSI 3085 nanoDMA at equivalent aerosol flow rates.

Conclusions:

  • The developed low-flow mDMA is a viable component for constructing compact, field-portable mobility spectrometers.
  • Its performance characteristics, including size classification accuracy and resolution, are suitable for nanoparticle and submicrometer aerosol measurements.
  • The mDMA's design facilitates low-cost fabrication and easy assembly, promoting wider adoption in field-based aerosol research.