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Chromatin Isolation by RNA Purification ChIRP

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Non-coding RNAs as regulators in epigenetics (Review).

Jian-Wei Wei¹, Kai Huang¹, Chao Yang¹

¹Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Key Laboratory of Post-trauma Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of the Nervous System, Tianjin 300052, P.R. China.

Oncology Reports

|November 15, 2016

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Epigenetics involves gene expression changes without altering DNA. Recent research highlights non-coding RNAs (ncRNAs) as key regulators in epigenetic networks, influencing cell growth, differentiation, and diseases like cancer.

Area of Science:

Epigenetics and molecular biology.

Background:

Epigenetic regulation influences gene expression without DNA sequence changes.
Key mechanisms include DNA methylation, histone modifications, and non-coding RNAs.
Non-coding RNAs (ncRNAs) are increasingly recognized for their regulatory roles.

Purpose of the Study:

To summarize recent research on non-coding RNAs (ncRNAs).
To elucidate the mechanisms of action of ncRNAs in cellular processes.
To understand the role of ncRNAs in epigenetic regulatory networks.

Main Methods:

Review of current scientific literature on non-coding RNAs and epigenetics.
Analysis of studies investigating ncRNA functions and mechanisms.
Synthesis of evidence linking ncRNAs to epigenetic control.

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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

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Last Updated: Mar 12, 2026

Chromatin Isolation by RNA Purification ChIRP

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CARIP-Seq and ChIP-Seq: Methods to Identify Chromatin-Associated RNAs and Protein-DNA Interactions in Embryonic Stem Cells

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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

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Published on: March 1, 2019

Main Results:

Non-coding RNAs (ncRNAs) are crucial regulators of gene expression.
Specific ncRNAs like miRNAs, piRNAs, siRNAs, and lncRNAs are prominent.
Growing evidence indicates ncRNAs play significant roles in epigenetic regulation.

Conclusions:

Non-coding RNAs (ncRNAs) are integral to epigenetic regulatory networks.
Understanding ncRNA mechanisms provides insight into gene expression control.
These findings underscore the critical role of RNA in epigenetics.