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Updated: Mar 12, 2026

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Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
Published on: September 6, 2024
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Metastable hydrogels from aromatic dipeptides
M P Conte1, N Singh2, I R Sasselli1
1WestCHEM/Department of Pure & Applied Chemistry, University of Strathclyde, 99 George Street, Glasgow, G1 1RD, UK.
Abstract:
We demonstrate that the well-known self-assembling dipeptide diphenylalanine (FF) and its amidated derivative (FF-NH2) can form metastable hydrogels upon sonication of the dipeptide solutions. The hydrogels show instantaneous syneresis upon mechanical contact resulting in rapid expulsion of water and collapse into a semi-solid gel.

