Related Experiment Video

Updated: Mar 12, 2026

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice
06:27

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice

Published on: July 20, 2022

3.3K

High Prevalence of Diastolic Dysfunction in Incident Patients on Peritoneal Dialysis: Association with Low Thyroid

Virginia Sánchez1, Ramón Paniagua, Maria Del Carmen Prado

  • 1Unidad de Investigación Médica en Enfermedades Nefrológicas, Hospital de Especialidades, CMN, SXXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.

Nephron
|November 15, 2016
PubMed

Insights

Diastolic dysfunction (DD) is common in peritoneal dialysis (PD) patients. Low triiodothyronine (T3) levels are an independent risk factor for severe DD, suggesting a link between thyroid hormones and cardiac health in kidney disease.

Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Diastolic dysfunction (DD) and low thyroid hormones (TH) are prevalent in chronic kidney disease (CKD) and linked to mortality.
  • The relationship between DD and TH in CKD patients on peritoneal dialysis (PD) remains unclear.

Purpose of the Study:

  • To investigate DD as a potential marker of fibrosis.
  • To analyze the association between DD and TH levels in incident PD patients.

Main Methods:

  • Cross-sectional study of 183 incident PD patients with preserved ejection fraction.
  • Assessed serum total and free triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone.
  • Evaluated left ventricular (LV) mass and DD using echocardiography and tissue Doppler imaging.

Main Results:

  • 62% of patients exhibited some degree of DD, with 36% having grade III DD.
  • Grade III DD was associated with diabetes mellitus (DM), older age, high LV mass, and lower T3/T4 levels.
  • Logistic regression identified DM, hypertension, and total T3 (tT3) as independent risk factors for grade III DD.

Conclusions:

  • A high prevalence of grade III DD was observed in incident PD patients.
  • Total T3 emerged as an independent risk factor for severe DD, alongside DM and hypertension.
  • Further research is warranted to elucidate the underlying mechanisms of this association.
Abstract

More Related Videos

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

16.2K
Assessment of Vascular Function in Patients With Chronic Kidney Disease08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.9K

Related Concept Videos

Peritoneal Dialysis III: Nursing Management01:25

Peritoneal Dialysis III: Nursing Management

Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
1.2K
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
1.3K
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
565
Peritoneal Dialysis I: Introduction and Procedure01:30

Peritoneal Dialysis I: Introduction and Procedure

Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...
5.0K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
864
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
494