Related Experiment Videos
Polymorphonuclear leucocyte motility in men with ankylosing spondylitis
C T Pease1, M Fennell, D A Brewerton
1Department of Rheumatology, Westminster Hospital, London.
Annals of the Rheumatic Diseases
|January 1, 1989
Summary
Men with ankylosing spondylitis (AS) show an enhanced polymorphonuclear leucocyte (PMN) response to stimuli. This heightened PMN motility is specific to AS and not seen in other inflammatory conditions.
Area of Science:
- Immunology
- Rheumatology
- Cell Biology
Background:
- Ankylosing spondylitis (AS) is a chronic inflammatory disease.
- Polymorphonuclear leucocytes (PMNs) play a key role in inflammatory responses.
- The specific behavior of PMNs in AS requires further investigation.
Purpose of the Study:
- To investigate the chemotactic and chemokinetic response of PMNs in men with ankylosing spondylitis.
- To determine if enhanced PMN motility in AS is related to disease activity, acute phase response, or HLA-B27 status.
- To differentiate AS-specific PMN behavior from other inflammatory conditions.
Main Methods:
- Assessing PMN response to chemotactic and chemokinetic stimuli in AS patients.
- Correlating PMN function with disease activity markers and acute phase response.
- Evaluating PMN function in HLA-B27 positive relatives and patients with psoriasis or Crohn's disease.
Main Results:
- PMN response to stimuli is significantly enhanced in men with AS.
- This enhancement is independent of disease severity, acute phase response, or NSAID treatment.
- PMN function is normal in HLA-B27 positive individuals without AS and in patients with psoriasis or Crohn's disease.
Conclusions:
- Enhanced PMN motility is a characteristic feature of ankylosing spondylitis.
- This heightened motility is specific to AS and not a general inflammatory response.
- The findings suggest a unique aspect of immune cell behavior in AS pathogenesis.