Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

2.2K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.2K
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

1.2K
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
1.2K
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

50.2K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
50.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A personalized view on how artificial intelligence will change the future of multidirectional cell therapy: From design and engineering foundation to some healthcare applications.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026
Same author

What's happening? Editorial comment: Insights on artificial intelligence, cell therapy and stem cell transplantation safety.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026
Same author

An in-depth synthetic wrap on the immune-hemostatic axis in human disease.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026
Same author

Editorial comments: Human Defence Mechanism. Platelet and Red Cell Washing.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026
Same author

Editorial Commentary - From concepts to outcomes: A brief narrative of perspectives on integrating laboratory innovation to advance understanding of immunothrombosis/thromboinflammation, uncertainty in hemoglobin evaluation, and controversy in ABO incompatibility.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026
Same author

Editorial commentary - Reflections on integrating some rapidly evolving essential developments into blood transfusion practice, with fresh eyes on innovation and operational excellence: Current status and future opportunities.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2025

Related Experiment Video

Updated: Mar 12, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

10.4K

Hepatitis E virus: Emerging from the shadows in developed countries.

Harry R Dalton1, Jerard Seghatchian2

  • 1Royal Cornwall Hospital and University of Exeter, Truro, UK.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|November 16, 2016
PubMed
Summary

Hepatitis E virus (HEV) was long thought to be an imported disease in developed nations. Recent findings reveal HEV genotype 3 (gt3) circulates undetected in local animal populations and humans.

Keywords:
Blood productsEpidemiologyHepatitis E virus (HEV)PigsZoonosis

More Related Videos

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
09:35

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Published on: February 1, 2017

14.1K
Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.9K

Related Experiment Videos

Last Updated: Mar 12, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

10.4K
Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
09:35

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Published on: February 1, 2017

14.1K
Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.9K

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health

Background:

  • Hepatitis E virus (HEV) discovered in the 1980s is endemic in developing countries, spread via fecal-oral route by genotypes 1 and 2.
  • HEV infection typically causes self-limiting hepatitis in young adults, with outbreaks in areas with poor sanitation.
  • A critical exception is pregnant women, who face a 20-25% mortality rate from fulminant hepatic failure and obstetric complications.

Purpose of the Study:

  • To re-evaluate the prevalence and transmission dynamics of Hepatitis E virus in developed countries.
  • To investigate the potential for zoonotic transmission of HEV genotypes in non-endemic regions.

Main Methods:

  • Review of historical HEV data and epidemiological surveillance.
  • Analysis of HEV genotypes circulating in human and animal populations in developed countries.

Main Results:

  • HEV was historically misclassified as solely an imported disease in developed nations.
  • HEV genotype 3 (gt3) has been circulating undetected in humans, pigs, and other animals within developed countries.

Conclusions:

  • The understanding of HEV epidemiology in developed countries requires significant revision.
  • HEV gt3 represents a substantial, previously unrecognized public health concern due to its enzootic presence in animal reservoirs and potential for human infection.