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Updated: Mar 12, 2026
04:30
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
26.5K
Drug eluting stents: To evolve or dissolve?
Prashant Bharadwaj1, D S Chadha2
1Consultant (Medicine & Cardio), Military Hospital (Cardio Thoracic Center), Pune 411040, India.
Medical Journal, Armed Forces India
|November 16, 2016
Summary
Drug-eluting stents (DES) revolutionized coronary artery disease treatment by reducing restenosis. Newer DES generations address very late stent thrombosis, improving patient outcomes in percutaneous coronary intervention.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Biomaterials Science
Background:
- Percutaneous coronary intervention (PCI) is a cornerstone in treating coronary artery disease.
- Early bare metal stents and angioplasty faced high restenosis rates, necessitating repeat procedures.
- Understanding in-stent restenosis (ISR) and neointimal hyperplasia drove the development of drug-eluting stents (DES).
Approach:
- This review traces the technological and pharmacological evolution of DES.
- It examines the initial success of DES in mitigating ISR.
- The review also addresses the emergence and understanding of very late stent thrombosis (VLST) associated with DES.
Key Points:
- DES significantly reduced ISR compared to bare metal stents.
- Very late stent thrombosis (VLST) emerged as a concern with early DES.
- Pathological insights have guided the development of newer generation DES with improved safety profiles.
Conclusions:
- DES have transformed coronary interventions over the past four decades.
- Ongoing research and development focus on optimizing DES efficacy and safety.
- The evolution of DES reflects a continuous effort to improve treatment for coronary artery disease.
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