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Recent developments and translational aspects in targeted therapy for metastatic breast cancer

Maximilian Marhold1, Rupert Bartsch1, Christoph Zielinski1

  • 1Department for Internal Medicine I-Oncology , Comprehensive Cancer Center and Medical University Vienna , Vienna , Austria.

ESMO Open
|November 16, 2016
PubMed

Insights

Metastatic breast cancer (MBC) has diverse molecular subtypes driving disease progression. This review summarizes new targeted therapies and translational research for MBC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Translational Medicine

Background:

  • Metastatic breast cancer (MBC) exhibits significant molecular heterogeneity, with distinct subtypes identified.
  • Recent research has identified oncogenic drivers within MBC subtypes as potential therapeutic targets.

Approach:

  • This review synthesizes current therapeutic strategies for MBC.
  • It focuses on clinical trial results targeting known cancer-promoting pathways.
  • The review also discusses translational aspects of these therapies.

Key Points:

  • Understanding MBC subtypes is crucial for effective treatment.
  • Targeting specific oncogenic pathways shows promise in clinical trials.
  • Translational research bridges laboratory findings with clinical application in MBC.

Conclusions:

  • New therapeutic avenues are emerging for metastatic breast cancer based on molecular subtyping.
  • Targeted therapies offer improved treatment strategies for MBC patients.
  • Continued translational research is essential for advancing MBC care.
Keywords:
BreastBreast CancerMetastatic Breast CancerTargeted TherapyTranslational Cancer Research

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