Related Experiment Video
Updated: Mar 12, 2026
10:04
Enhancing Tumor Content through Tumor Macrodissection
Published on: February 12, 2022
12.6K
Massive Upper Gastrointestinal Bleeding Caused by Diffuse Large B-Cell Lymphoma.
O Telci Caklili1, H H Mutlu2, Y Colak3
1Kocaeli State Hospital, Internal Medicine, Kocaeli, Turkey.
Case Reports in Gastrointestinal Medicine
|November 16, 2016
Summary
Diffuse large B-cell lymphoma (DLBCL) can cause rare but life-threatening upper gastrointestinal bleeding. This case highlights gastric DLBCL as a critical cause of massive bleeding, requiring urgent medical intervention.
Area of Science:
- Gastroenterology
- Hematology
- Oncology
Background:
- Massive upper gastrointestinal bleeding is a critical medical emergency.
- Hematological malignancies are uncommon causes of upper GI bleeding, typically originating in the duodenum.
Purpose of the Study:
- To present a rare case of gastric diffuse large B-cell lymphoma (DLBCL) causing massive upper gastrointestinal bleeding.
- To emphasize DLBCL as a potential cause of life-threatening GI hemorrhage.
Main Methods:
- Case report of a 77-year-old male presenting with hematemesis and hematochezia.
- Physical examination, vital signs monitoring, blood transfusion, and urgent gastroscopy with biopsy.
- Histopathological analysis of biopsy specimens.
Main Results:
- Patient presented with signs of severe bleeding and hemodynamic instability.
- Gastroscopy revealed a mosaic mucosal pattern and multiple gastric ulcers.
- Biopsy confirmed diffuse large B-cell lymphoma (DLBCL) of the stomach.
Conclusions:
- Gastric DLBCL, though rare, can manifest as massive upper gastrointestinal bleeding.
- Prompt diagnosis and intervention are crucial for managing life-threatening GI hemorrhage caused by gastric lymphoma.
Related Concept Videos
01:28Esophageal Varices-II: Clinical Features and Management
707
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
707
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
1.3K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.3K
01:24Esophageal Varices-I: Introduction
1.9K
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
1.9K
01:30Other Disorders of Digestive System
1.6K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.6K