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Massive Upper Gastrointestinal Bleeding Caused by Diffuse Large B-Cell Lymphoma.

O Telci Caklili1, H H Mutlu2, Y Colak3

  • 1Kocaeli State Hospital, Internal Medicine, Kocaeli, Turkey.

Case Reports in Gastrointestinal Medicine
|November 16, 2016
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This summary is machine-generated.

Diffuse large B-cell lymphoma (DLBCL) can cause rare but life-threatening upper gastrointestinal bleeding. This case highlights gastric DLBCL as a critical cause of massive bleeding, requiring urgent medical intervention.

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Area of Science:

  • Gastroenterology
  • Hematology
  • Oncology

Background:

  • Massive upper gastrointestinal bleeding is a critical medical emergency.
  • Hematological malignancies are uncommon causes of upper GI bleeding, typically originating in the duodenum.

Purpose of the Study:

  • To present a rare case of gastric diffuse large B-cell lymphoma (DLBCL) causing massive upper gastrointestinal bleeding.
  • To emphasize DLBCL as a potential cause of life-threatening GI hemorrhage.

Main Methods:

  • Case report of a 77-year-old male presenting with hematemesis and hematochezia.
  • Physical examination, vital signs monitoring, blood transfusion, and urgent gastroscopy with biopsy.
  • Histopathological analysis of biopsy specimens.

Main Results:

  • Patient presented with signs of severe bleeding and hemodynamic instability.
  • Gastroscopy revealed a mosaic mucosal pattern and multiple gastric ulcers.
  • Biopsy confirmed diffuse large B-cell lymphoma (DLBCL) of the stomach.

Conclusions:

  • Gastric DLBCL, though rare, can manifest as massive upper gastrointestinal bleeding.
  • Prompt diagnosis and intervention are crucial for managing life-threatening GI hemorrhage caused by gastric lymphoma.