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Left ventricular noncompaction diagnosed following Graves' disease
Habib Habib1, Amer Hawatmeh2, Upamanyu Rampal3
1Department of Cardiology, Saint Joseph Regional Medical Center, New York Medical College, New Jersey, USA.
Avicenna Journal of Medicine
|November 16, 2016
Summary
Isolated left ventricular noncompaction (LVNC), a rare heart condition, was diagnosed in a patient experiencing hyperthyroidism due to Graves' disease. This case highlights a novel trigger for LVNC manifestation, emphasizing its varied clinical presentations.
Area of Science:
- Cardiology
- Genetics
- Endocrinology
Background:
- Isolated left ventricular noncompaction (LVNC) is a rare genetic cardiomyopathy with variable clinical presentations, including heart failure, arrhythmias, and thromboembolism.
- LVNC can be asymptomatic, with manifestations appearing later in life, potentially triggered by unrelated conditions.
Observation:
- A case of LVNC was diagnosed in a patient who developed a hyperthyroid state secondary to Graves' disease.
- The patient presented with exacerbated contractile dysfunction, leading to the LVNC diagnosis.
Findings:
- This is the first reported case of LVNC diagnosed following Graves' disease-induced hyperthyroidism and exacerbated contractile dysfunction.
- While associations between LVNC and other noncardiac abnormalities (neurological, hematological, endocrine) have been noted, this specific trigger is novel.
Implications:
- This case expands the understanding of potential triggers for LVNC manifestation, particularly in the context of endocrine disorders.
- It underscores the importance of considering cardiac evaluation in patients with new-onset or exacerbated symptoms during conditions like Graves' disease.
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