Left ventricular noncompaction diagnosed following Graves' disease

Area of Science:

• Cardiology
• Genetics
• Endocrinology

Background:

• Isolated left ventricular noncompaction (LVNC) is a rare genetic cardiomyopathy with variable clinical presentations, including heart failure, arrhythmias, and thromboembolism.
• LVNC can be asymptomatic, with manifestations appearing later in life, potentially triggered by unrelated conditions.

Observation:

• A case of LVNC was diagnosed in a patient who developed a hyperthyroid state secondary to Graves' disease.
• The patient presented with exacerbated contractile dysfunction, leading to the LVNC diagnosis.

Findings:

• This is the first reported case of LVNC diagnosed following Graves' disease-induced hyperthyroidism and exacerbated contractile dysfunction.
• While associations between LVNC and other noncardiac abnormalities (neurological, hematological, endocrine) have been noted, this specific trigger is novel.

Implications:

• This case expands the understanding of potential triggers for LVNC manifestation, particularly in the context of endocrine disorders.
• It underscores the importance of considering cardiac evaluation in patients with new-onset or exacerbated symptoms during conditions like Graves' disease.