Related Experiment Video
Updated: Mar 12, 2026
Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions
Published on: June 5, 2019
Impact of disease control and co-existing risk factors on heart rate variability in Gujarati type 2 diabetics: An
Jayesh Dalpatbhai Solanki1, Sanket D Basida2, Hemant B Mehta1
1Department of Physiology, Government Medical College, Bhavnagar, Gujarat, India.
Insights
Type 2 diabetes significantly impairs cardiac autonomic function, as measured by heart rate variability (HRV). Poor glycemic control did not further worsen HRV, suggesting diabetes itself is the primary driver of cardiac dysautonomia.
Area of Science:
- Cardiology
- Endocrinology
- Autonomic Nervous System Research
Background:
- Type 2 diabetes mellitus (T2DM) is a significant risk factor for cardiac dysautonomia.
- Limited research exists on cardiac autonomic status in Indian T2DM populations, particularly concerning disease control and comorbidities like hypertension.
- Heart rate variability (HRV) is a noninvasive method to assess cardiac autonomic function.
Purpose of the Study:
- To investigate HRV parameters in type 2 diabetic patients.
- To evaluate the impact of glycemic control and co-existing risk factors on cardiac autonomic function in T2DM.
- To explore the prevalence of cardiac dysautonomia in a Gujarati T2DM cohort.
Main Methods:
- Ninety-eight hypertensive and forty normotensive Gujarati T2DM patients were assessed.
- Disease control and cardiovascular risk factors were evaluated.
- Standardized 5-minute resting HRV recordings were performed using Variowin HR software.
- Time domain, frequency domain, and Poincare plot HRV parameters were analyzed.
Main Results:
- All HRV parameters were reduced in T2DM patients (mean age 56 years, mean duration 6 years) with poor glycemic control.
- No significant differences in HRV were observed between subgroups with good versus poor glycemic control.
- HRV parameters did not significantly differ based on optimal blood pressure control or the presence of individual cardiovascular risk factors, except for resting heart rate.
Conclusions:
- Diabetes mellitus is a primary cause of cardiac dysautonomia, irrespective of glycemic control or presence of cardiovascular risk factors.
- Reduced HRV in T2DM patients indicates residual cardiovascular risk despite treatment.
- There is a need for HRV screening, stringent glycemic management, and further research in T2DM populations.
Background:
Type 2 diabetes mellitus (T2DM) is a proven threat of cardiac dysautonomia with paucity of studies from India. Poor disease control makes it further worse with co-existence of hypertension in majority. Heart rate variability (HRV) is a validated noninvasive tool to assess cardiac autonomic status.
Aim:
We studied HRV parameters of type 2 diabetics looking for effects of disease control and other co-existing risk factors.
Materials And Methods:
Ninety-eight hypertensive and forty normotensive under-treatment, Gujarati type 2 diabetics were evaluated for disease control and risk stratification. Five minutes resting, HRV was measured by Variowin HR, software-based instrument, using standard protocols to record time domain, frequency domain, and Poincare plot HRV parameters. They were compared between subgroups for the difference with P < 0.05 defining statistical significance.
Results:
All HRV parameters were reduced in type 2 diabetics, having mean age 56 years, mean duration 6 years with poor glycemic but comparatively better pressure control. HRV parameters were significantly not different in good compared to poor glycemics or in subjects with optimum pressure control than those without it. Results did not differ significantly, by the presence of individual cardiovascular risk factor in diabetics except resting heart rate.
Conclusion:
Our findings of HRV suggest that type 2 diabetics with poor glycemic control do not have a significant difference of cardiac dysautonomia by pressure control, glycemic control, and absence of risk cardiovascular factor. It suggests diabetes as a major cause for cardiac dysautonomia, residual risk despite treatment and need for HRV screening, strict glycemic control, and further studies.
More Related Videos
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
05:16Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Related Concept Videos
01:30Factors Influencing Heart Rate
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
01:22Diabetes Mellitus: Type 2 and Gestational
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
01:30Coronary Artery Disease I: Introduction
01:21Rheumatic Heart Disease III: Medical Management
01:28Factors affecting Blood pressure
Physiological Factors: