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Does Omega-3 supplementation decrease carotid intima-media thickening in hemodialysis patients?

Mohammad Hossein Kajbaf1, Fariborz Khorvash2, Mojgan Mortazavi3

  • 1Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Journal of Research in Pharmacy Practice
|November 16, 2016
PubMed

Insights

Omega-3 supplementation significantly reduced atherosclerosis progression in hemodialysis patients. This intervention also improved HDL levels and urea reduction ratio, suggesting a protective role.

Area of Science:

  • Cardiovascular Science
  • Nephrology
  • Nutritional Science

Background:

  • Atherosclerosis is a major complication in hemodialysis (HD) patients.
  • Omega-3 fatty acids possess anti-inflammatory and cardioprotective properties.
  • The impact of omega-3 supplementation on atherosclerosis progression in HD patients requires further investigation.

Purpose of the Study:

  • To evaluate the effect of omega-3 supplementation on the progression of atherosclerosis.
  • To measure changes in carotid intima-media thickness (cIMT) as a marker of atherosclerosis.
  • To assess the efficacy of omega-3 in hemodialysis patients.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial was conducted.
  • 54 hemodialysis patients were randomized into two groups: omega-3 (3 g/day) or placebo for 6 months.
  • Carotid artery ultrasound was used to measure cIMT at baseline and 6 months.

Main Results:

  • Omega-3 supplementation significantly decreased cIMT (P < 0.001).
  • The placebo group showed a nonsignificant increase in cIMT (P = 0.12).
  • Significant differences in cIMT, HDL levels, and urea reduction ratio were observed between groups.

Conclusions:

  • Omega-3 supplementation demonstrates a protective effect against atherosclerosis progression in hemodialysis patients.
  • The findings support the use of omega-3 as an adjunct therapy in managing cardiovascular risk in HD patients.
  • Further research may explore long-term outcomes and optimal dosages.
Abstract

Keywords:
Cardiovascular diseaseOmega-3carotid intima-media thicknesshemodialysis

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