Related Experiment Video
Updated: Mar 12, 2026
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
9.8K
[Clinical importance of HDL cholesterol]
W März1,2,3, M E Kleber1,4, H Scharnagl2
1Medizinische Klinik V (Nephrologie, Hypertensiologie, Rheumatologie, Endokrinologie, Diabetologie), Medizinische Fakultät Mannheim der Universität Heidelberg, Heidelberg, Deutschland.
Herz
|November 16, 2016
Summary
High-density lipoprotein cholesterol (HDL-C) levels are less critical for cardiovascular risk than previously thought. Lifestyle changes can improve HDL-C, but it is not a drug therapy target.
Area of Science:
- Cardiology
- Clinical Chemistry
Background:
- Millions of high-density lipoprotein cholesterol (HDL-C) tests are performed annually in Germany.
- Recent data necessitate a reevaluation of HDL-C's clinical importance.
Purpose of the Study:
- To review the current understanding of HDL-C's role in cardiovascular risk.
- To assess the clinical utility of HDL-C measurements and ratios.
Main Methods:
- Selective literature search for review article.
- Analysis of epidemiological data and biological functions of HDL.
Main Results:
- Low HDL-C correlates with increased cardiovascular risk, though the relationship is complex.
- HDL-C concentration doesn't reflect HDL's protective functions; altered composition can be detrimental.
- HDL-C is secondary to low-density lipoprotein cholesterol (LDL-C) for risk stratification.
Conclusions:
- The LDL-C:HDL-C ratio is not universally applicable for risk assessment.
- Low HDL-C warrants investigation for underlying metabolic or inflammatory conditions.
- Lifestyle improvements (smoking cessation, exercise) positively impact HDL-C, but it's not a target for drug therapy.
Related Concept Videos
01:29Cholesterol: Significance and Regulation
1.8K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
1.8K
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
730
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
730
01:18Lipids: Dietary Sources and Requirements
2.5K
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
2.5K
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
1.6K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.6K
01:26Coronary Artery Disease IV: Preventive Measures
790
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
790
01:31Lipid-derived Compounds in the Human Body
7.2K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
7.2K