Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aqueous humor composition in Fuchs' dystrophy.

S E Wilson1, W M Bourne, L J Maguire

  • 1Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905.

Investigative Ophthalmology & Visual Science
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterisation and comparison of Mycoplasma bovis strain types from Irish and Scottish bovine isolates in a global context.

Veterinary microbiology·2024
Same author

The Role of Speech and Language Therapy in Assessing and Managing Pharyngo-esophageal Diverticula.

Irish medical journal·2016
Same author

Organ donation following the circulatory determination of death (DCD): an audit of donation and outcomes following renal transplantation.

Irish medical journal·2014
Same author

Comparative analysis of histopathologic responses to implanted porcine biologic meshes.

Hernia : the journal of hernias and abdominal wall surgery·2013
Same author

External fluorescence retention of calcein-marked juvenile brown trout Salmo trutta raised in natural and artificial environments.

Journal of fish biology·2013
Same author

Non heart beating organ donation in adults: a clinical practice guideline.

Irish medical journal·2013

This study found no significant differences in aqueous humor composition, including fibrinogen levels, between Fuchs

Area of Science:

  • Ophthalmology
  • Corneal Diseases
  • Ocular Biochemistry

Background:

  • Fuchs' dystrophy is a progressive corneal disease.
  • Previous research suggested altered aqueous humor composition in Fuchs' dystrophy, particularly elevated fibrinogen-related factors.

Purpose of the Study:

  • To investigate potential differences in aqueous humor composition between eyes with Fuchs' dystrophy and control eyes.
  • To specifically examine levels of fibrinogen-related factors, ascorbate, glucose, and other parameters.

Main Methods:

  • Aqueous humor samples were collected during surgery from patients with Fuchs' dystrophy and cataracts, and from control patients with cataracts alone.
  • Total fibrinogen-related antigen and small molecular weight fibrinogen-derived metabolites were quantified using enzyme-linked immunosorbent assay (ELISA).

Related Experiment Videos

  • Aqueous humor ascorbate, glucose, carbon dioxide, bicarbonate, and pH were also measured.

    • Main Results:

    • No statistically significant differences were found in total fibrinogen-related antigen levels between the Fuchs' dystrophy group and the control group.
    • No significant differences were observed in fibrinogen-derived metabolites, ascorbate, glucose, carbon dioxide, bicarbonate, or pH.

    Conclusions:

    • This study found no evidence of altered aqueous humor composition in Fuchs' dystrophy.
    • The findings support the hypothesis that Fuchs' dystrophy is primarily a disorder of the corneal endothelium.