Related Experiment Video

Updated: Mar 12, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.6K

miR-27b inhibits gastric cancer metastasis by targeting NR2F2

Qingzhao Feng1, Xionglin Wu2, Fuchao Li3

  • 1Department of General Surgery, The Affiliated Drum Tower Hospital of Medical School of Nanjing University, Nanjing, 210008, China. izaobao@vip.qq.com.

Protein & Cell
|November 16, 2016
PubMed

Insights

Nuclear receptor subfamily 2 (NR2F2) is upregulated in gastric cancer, promoting tumor growth. MicroRNA-27b acts as a tumor suppressor, and its down-regulation by NR2F2 indicates poor patient survival.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are increasingly recognized for their role in cancer development, often through down-regulation.
  • Nuclear receptor subfamily 2 (NR2F2), also known as COUP-TFII, is implicated in various cancers, but its specific function in gastric cancer is not well understood.

Purpose of the Study:

  • To investigate the role of NR2F2 and its potential interaction with microRNAs in gastric cancer.
  • To determine the prognostic significance of NR2F2 expression in gastric cancer patients.

Main Methods:

  • Utilized Oncomine and Kaplan-Meier databases to analyze NR2F2 expression and survival data.
  • Investigated the regulatory relationship between NR2F2 and microRNA-27b in gastric cancer cells and tissues.
  • Assessed the functional impact of miR-27b on gastric cancer cell proliferation, migration, invasion, and metastasis in vitro and in vivo.

Main Results:

  • NR2F2 was found to be significantly upregulated in gastric cancer, with high expression correlating with poorer patient survival.
  • NR2F2 was identified as a direct regulator that down-regulates microRNA-27b (miR-27b) in gastric cancer.
  • Overexpression of miR-27b suppressed gastric cancer cell proliferation and tumor growth, while also inhibiting migration and invasion.
  • Down-regulation of miR-27b promoted proliferation and metastasis of gastric cancer cells.

Conclusions:

  • miR-27b functions as a tumor suppressor in gastric cancer.
  • NR2F2-mediated down-regulation of miR-27b contributes to gastric cancer progression.
  • miR-27b holds potential as a biomarker for predicting survival in gastric cancer patients.
Keywords:
NR2F2gastric cancermiR-27btumor metastasis

More Related Videos

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

831
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.9K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.5K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.3K