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Published on: June 3, 2018
The expression of Smad signaling pathway in myocardium and potential therapeutic effects
Yuping Duan1,2, Wei Zhu3, Min Liu2
1School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, P.R. China.
Abstract:
Myocardial infarction (MI) is a life-threatening disease. The expression of Smad proteins in the ischemic myocardium changes significantly following myocardial infarction, suggesting a close relationship between Smad proteins and heart remodeling. Moreover, it is known that the expression of Smads is regulated by transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMP). Based on these findings, regulating the expression of Smad proteins by targeting TGF-β and BMP in the ischemic myocardium may be considered to be a possible therapeutic strategy for the treatment of myocardial infarction.

