Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Some immunomodulating factors in allergic contact dermatitis.

G Roupe

    Acta Dermato-Venereologica. Supplementum
    |January 1, 1978
    PubMed
    Summary

    Thymectomy in mice counteracts age-related decline in contact sensitivity but reduces antibody production. This suggests long-lived thymus-dependent suppressor cells regulate contact sensitivity without impacting antibody formation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Skin of the aging human being].

    Lakartidningen·2001
    Same author

    Microdialysis of histamine in the skin of patients with mastocytosis.

    Experimental dermatology·2001
    Same author

    Cytogenetic studies in patients with mastocytosis.

    Cancer genetics and cytogenetics·2000
    Same author

    Serum tryptase measured with B12 and G5 antibody-based immunoassays in mastocytosis patients and its relation to histamine turnover.

    The British journal of dermatology·1999
    Same author

    PUVA in early mycosis fungoides may give long-term remission and delay extracutaneous spread.

    Acta dermato-venereologica·1996
    Same author

    Histamine metabolism in mastocytosis patients treated with interferon alpha-2b.

    Inflammation research : official journal of the European Histamine Research Society ... [et al.]·1996

    Area of Science:

    • Immunology
    • Developmental Biology

    Background:

    • The thymus plays a crucial role in immune system development and regulation.
    • Age-related changes in immune responses, such as decreased contact sensitivity, are well-documented.

    Purpose of the Study:

    • To investigate the impact of adult thymectomy on antibody production and contact sensitivity in mice of varying ages.
    • To explore the role of thymus-dependent regulatory mechanisms in immune responses.

    Main Methods:

    • Adult thymectomy was performed on mice of different ages.
    • Contact sensitivity to picryl chloride was assessed.
    • Antibody production was measured.

    Main Results:

    • Thymectomy counteracted the age-dependent decline in the ability to develop contact sensitivity.
    • Antibody production was consistently decreased by thymectomy across all age groups.
    • These findings suggest the involvement of long-lived thymus-dependent suppressor cells in regulating contact sensitivity.

    Conclusions:

    • The thymus influences age-dependent immune responses, specifically contact sensitivity, through mechanisms distinct from antibody production.
    • Long-lived thymus-dependent suppressor cells appear to regulate contact sensitivity development without affecting antibody formation.

    Related Experiment Videos