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Updated: Mar 12, 2026
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Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
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Pustular eruption associated with granulocyte colony-stimulating factor treatment
Maria B Brumana1, Irene Russo1, Renato Zambello2
1Unit of Dermatology, University of Padua, Padua, Italy.
Summary
A patient with Hodgkin lymphoma developed a facial pustular rash during treatment with granulocyte colony-stimulating factor. This skin reaction was linked to neutrophil levels and G-CSF administration, not infection.
Area of Science:
- Oncology
- Dermatology
- Hematology
Background:
- Hodgkin lymphoma treatment often involves chemotherapy leading to neutropenia.
- Granulocyte colony-stimulating factor (G-CSF) is used to manage chemotherapy-induced neutropenia.
- Skin reactions can occur as adverse effects of cancer therapies.
Observation:
- A patient with Hodgkin lymphoma presented with a localized pustular eruption on the face.
- The eruption coincided with G-CSF administration for neutropenia.
- Neutrophil counts closely correlated with the pustular rash activity.
Findings:
- Infective causes were ruled out by negative cultures.
- The skin reaction is hypothesized to be a direct effect of G-CSF.
- Neutrophil accumulation driven by G-CSF is proposed as the mechanism.
Implications:
- This case highlights a potential G-CSF-induced dermatological side effect in lymphoma patients.
- Awareness of this reaction can aid in differential diagnosis and patient management.
- Further investigation into G-CSF's cutaneous effects may be warranted.
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