Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sleep deprivation in the rat: VII. Immune function.

R M Benca1, C A Kushida, C A Everson

  • 1Department of Psychiatry, University of Chicago, Illinois 60637.

Sleep
|February 1, 1989
PubMed
Summary

Sleep deprivation did not suppress immune function in rats. Studies on splenic lymphocytes showed no significant differences in cell counts or responses to antigens and mitogens compared to control groups.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between pre-operative adherence to positive airway pressure therapy and postoperative opioid use after lower limb arthroplasty in patients with obstructive sleep apnoea.

Anaesthesia reports·2026
Same author

Impact of continuous positive airway pressure in patients with obstructive sleep apnea during drug-induced sleep endoscopy.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2017
Same author

Effects of oral temazepam on slow waves during non-rapid eye movement sleep in healthy young adults: A high-density EEG investigation.

International journal of psychophysiology : official journal of the International Organization of Psychophysiology·2016
Same author

Effects of oral temazepam on sleep spindles during non-rapid eye movement sleep: A high-density EEG investigation.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2015
Same author

Altered overnight modulation of spontaneous waking EEG reflects altered sleep homeostasis in major depressive disorder: a high-density EEG investigation.

Journal of affective disorders·2013
Same author

Topographic and sex-related differences in sleep spindles in major depressive disorder: a high-density EEG investigation.

Journal of affective disorders·2012

Area of Science:

  • Immunology
  • Sleep Science
  • Neuroscience

Background:

  • Sleep is crucial for physiological functions, including immune response.
  • Previous research suggests sleep deprivation may negatively impact immunity.
  • Understanding the relationship between sleep and immune function is vital for public health.

Purpose of the Study:

  • To investigate the effects of total and paradoxical sleep deprivation on immune function in rats.
  • To determine if sleep deprivation leads to immune suppression.

Main Methods:

  • Immune function was assessed in rats undergoing total or paradoxical sleep deprivation.
  • Splenic lymphocytes were analyzed for cell counts.
  • In vitro and in vivo lymphocyte proliferation and plaque-forming cell responses to mitogens and antigens were measured.

Related Experiment Videos

Main Results:

  • Sleep-deprived rats exhibited spleen cell counts comparable to their yoked and home-cage controls.
  • In vitro and in vivo immune responses to mitogens and antigens were similar across all groups.
  • No statistically significant differences were observed in any of the immune assays performed.

Conclusions:

  • The study's findings do not support the hypothesis that sleep deprivation causes immune suppression.
  • Immune parameters measured in this study remained unaffected by total or paradoxical sleep deprivation in rats.
  • Further research may be needed to explore other immune markers or different sleep deprivation models.