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Oral Health Assessment by Lay Personnel for Older Adults
08:47

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

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Oral health and coronary heart disease

Marc J Mathews1, Edward H Mathews1, George E Mathews2

  • 1CRCED, North-West University, P.O. Box 11207, Silver Lakes, 0054, South Africa.

BMC Oral Health
|November 17, 2016
PubMed

Insights

A new integrated model clarifies the link between periodontal disease and coronary heart disease (CHD). This model helps understand how gum disease may impact heart health through various biological pathways.

Area of Science:

  • Cardiovascular Science
  • Oral Health Research
  • Biomedical Modeling

Background:

  • A documented correlation exists between periodontal disease and coronary heart disease (CHD).
  • The exact nature of this association, whether causal or due to shared factors like inflammation, remains unclear.
  • Existing literature lacks a comprehensive model to explain the pathogenetic pathways linking periodontal disease to CHD.

Purpose of the Study:

  • To develop an integrated model of coronary heart disease (CHD) pathways.
  • To investigate potential links between periodontal disease and CHD biomarkers using this model.
  • To elucidate the association between oral health and cardiovascular disease.

Main Methods:

  • Utilized a previously established integrated model of CHD.
  • Applied the model to explore pathogenetic pathways connecting periodontal disease to CHD.
  • Developed a novel 'connection graph' to simplify and visualize interactions.

Main Results:

  • An integrated model was created to offer insights into higher-order biological interactions between CHD and periodontal disease.
  • The connection graph quantitatively illustrates the relationship between periodontal disease and serological CHD biomarkers.
  • Identified potential pathways through which periodontitis pathogenesis may influence CHD pathogenesis.

Conclusions:

  • An integrated CHD model was successfully developed, summarizing potential cardiovascular effects of periodontal disease.
  • The model provides a framework for understanding the link between gum disease and heart health.
  • Further research is recommended to refine and validate the developed model.
Abstract

Keywords:
BiomarkersCoronary heart diseaseIntegrated modelPeriodontal disease

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