Triptolide inhibits the migration and invasion of human prostate cancer cells via Caveolin-1/CD147/MMPs pathway

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Updated: Mar 12, 2026

Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment
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Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment

Published on: November 23, 2017

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Shiqi Yuan1, Liping Wang1, Xixi Chen2

  • 1Department of Biochemistry, Dalian Medical University, 9 South Lvshun Road Western Section, Dalian 116044, Liaoning, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|November 17, 2016
PubMed

Insights

Triptolide effectively inhibits prostate cancer cell migration and invasion by targeting the Caveolin-1/CD147/MMPs pathway. This study clarifies triptolide

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Prostate cancer (PCa) is a leading cause of cancer death in men.
  • Triptolide, from Tripterygium wilfordii, shows broad anti-tumor activity.
  • The impact of triptolide on prostate cancer cell migration and invasion requires further investigation.

Purpose of the Study:

  • To investigate the effect of triptolide on prostate cancer cell migration and invasion.
  • To elucidate the underlying molecular mechanisms, focusing on Caveolin-1 (Cav-1).

Main Methods:

  • Prostate cancer cell lines were treated with triptolide in a time- and dose-dependent manner.
  • Expression levels of Cav-1, CD147, and Matrix Metalloproteinases (MMPs) were analyzed at mRNA and protein levels.
  • Cav-1 knockdown and rescue experiments were performed to validate its role.

Main Results:

  • Triptolide significantly inhibited prostate cancer cell proliferation, migration, and invasion.
  • Triptolide treatment reduced the expression of Cav-1, CD147, and MMPs.
  • Co-treatment with triptolide and Cav-1 knockdown potentiated anti-migration and anti-invasion effects.

Conclusions:

  • Triptolide suppresses prostate cancer cell migration and invasion via the Cav-1/CD147/MMPs pathway.
  • Triptolide demonstrates potential as a therapeutic agent for aggressive prostate cancer.
  • Understanding this pathway provides insights for clinical applications of triptolide.
Keywords:
InvasionMigrationProstate cancerTriptolide

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