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Abnormal Brain Responses to Action Observation in Complex Regional Pain Syndrome.

Jaakko Hotta1, Jukka Saari2, Miika Koskinen3

  • 1Systems and Clinical Neuroscience, Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland; Aalto NeuroImaging, Aalto University School of Science, Espoo, Finland; Department of Neurology, Helsinki University Hospital, and Clinical Neurosciences, Neurology, University of Helsinki, Finland.

The Journal of Pain
|November 17, 2016
PubMed
Summary

Complex regional pain syndrome (CRPS) alters brain activity during action observation. This neuroimaging study reveals impaired motor control and pain processing in CRPS patients compared to healthy individuals.

Keywords:
Action observationCRPSchronic painfMRImultivoxel pattern analysis

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Area of Science:

  • Neuroscience
  • Pain Research
  • Motor Control

Background:

  • Complex regional pain syndrome (CRPS) is characterized by central motor function abnormalities.
  • Pain in CRPS is exacerbated by performing or observing motor actions.

Purpose of the Study:

  • To investigate abnormal brain responses to action observation in patients with CRPS.
  • To identify specific brain regions affected by action observation in CRPS.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to analyze brain activity.
  • 13 upper limb CRPS patients and 13 healthy controls viewed videos of hand actions.
  • Pattern-classification analysis identified differences in brain activation between groups.

Main Results:

  • Statistically significant differences in brain activation were found in CRPS patients compared to controls.
  • Affected areas include sensorimotor cortex, inferior frontal gyrus, secondary somatosensory cortex, inferior parietal lobule, orbitofrontal cortex, and thalamus.
  • These regions are crucial for pain processing and motor control.

Conclusions:

  • CRPS impairs the ability to observe actions, impacting sensorimotor functions.
  • Abnormal neural activity in key brain areas underlies action-observation deficits in CRPS.
  • Findings provide a cerebral basis for understanding action-observation impairments in CRPS.