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High Mobility Group Box-1: A Missing Link between Diabetes and Its Complications
Han Wu1, Zheng Chen1, Jun Xie1
1Department of Cardiology, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.
Abstract:
High mobility group box-1 (HMGB-1), a damage-associated molecular pattern, can be actively or passively released from various cells under different conditions and plays a pivotal role in the pathogenesis of inflammation and angiogenesis-dependent diseases. More and more evidence suggests that inflammation, in addition to its role in progression of diabetes, also promotes initiation and development of diabetic complications. In this review, we focus on the role of HMGB-1 in diabetes-related complications and the therapeutic strategies targeting HMGB-1 in diabetic complications.
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