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Functional Performance of Chitosan/Carbopol 974P NF Matrices in Captopril Tablets
Yuritze Alejandra Aguilar-López1, Leopoldo Villafuerte-Robles1
1Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional de México, Ciudad de México, Mexico.
Journal of Pharmaceutics
|November 17, 2016
Summary
Chitosan and Carbopol 974P NF interact electrostatically, forming more coherent matrices for captopril tablets. This enhances tablet compactibility and controls drug release, improving oral drug delivery systems.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Chitosan and Carbopol form polyelectrolyte complexes via electrostatic interactions.
- These complexes show potential as matrices for oral controlled release drug delivery.
Purpose of the Study:
- To assess the interaction between chitosan and Carbopol 974P NF particles.
- To evaluate the impact of this interaction on the technological performance of captopril tablets.
Main Methods:
- Powder mixtures of captopril with Carbopol 974P NF, chitosan, or their 1:1 mixture (10-30% polymer proportion) were prepared.
- Evaluated parameters included powder flow rate, compressibility index, tablet compactibility, and drug release behavior.
Main Results:
- Greater interaction was observed between oppositely charged polymer particles (chitosan and Carbopol) compared to individual polymers.
- This interaction resulted in more coherent matrices, restricted drug dissolution, improved tablet compactibility, and reduced powder flow.
Conclusions:
- Electrostatic interactions between chitosan and Carbopol 974P NF significantly enhance the technological properties of captopril tablets.
- The findings suggest potential for improved oral controlled release formulations using these polymer complexes.
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