Related Experiment Video
Updated: Jan 21, 2026
04:13
Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models
Published on: September 27, 2024
851
Mandibular bone necrosis after use of paraformaldehyde-containing paste
Chi-Hwan Lee1, Yoorina Choi1, Sujung Park1
1Department of Conservative Dentistry, Wonkwang University School of Dentistry, Iksan, Korea.
Restorative Dentistry & Endodontics
|November 17, 2016
Summary
Paraformaldehyde, a pulpotomy agent, can cause severe side effects like bone necrosis. This report details serious complications, including osteomyelitis, from using Depulpin, a paraformaldehyde-containing agent, during root canal treatment.
Area of Science:
- Endodontics
- Oral Surgery
- Dental Materials
Background:
- Paraformaldehyde has historical use as a pulpotomy agent.
- Concerns exist regarding its severe cytotoxic effects and potential for alveolar bone necrosis.
- Depulpin, a devitalizing paste with 49% paraformaldehyde, is less frequently used due to adverse events.
Observation:
- Two cases utilized Depulpin as a devitalizing agent during root canal therapy.
- Patients experienced gradual loss of sensibility in adjacent teeth.
- Gingival necrosis and osteomyelitis were observed post-treatment.
Findings:
- The use of Depulpin led to significant complications.
- Mandibular bone necrosis was a prominent adverse outcome.
- Paraformaldehyde-containing pastes pose serious risks when used as pulp devitalizing agents.
Implications:
- This case report highlights the severe risks associated with paraformaldehyde-based devitalizing agents.
- Clinicians should exercise extreme caution when considering such agents, especially in the mandible.
- Alternative, safer materials are recommended for pulp devitalization to prevent devastating complications like osteomyelitis.
Related Concept Videos
01:16Necrosis
6.4K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
6.4K
01:18Porosity in Cement Paste
434
The porosity of concrete is a measure of the void spaces within its structure. These spaces impact its strength and durability significantly. When water and cement interact, a chemical reaction called hydration creates a semi-solid paste. This paste includes combined water, making up approximately 23% of the cement's dry mass, and gel water, which fills minuscule voids known as gel pores, accounting for about 28% of the cement gel volume.
The balance of water to cement in the mix is...
The balance of water to cement in the mix is...
434
01:09Spongy Bone
7.6K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
7.6K
01:27Compact Bone
16.2K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.2K
01:29Bone Disorders
5.1K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.1K
01:12The Hyoid Bone
4.8K
The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
4.8K