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PI3K/Akt/mTOR Intracellular Pathway and Breast Cancer: Factors, Mechanism and Regulation

Var Ruchi Sharma1, Girish Kumar Gupta2, A K Sharma3

  • 1Department of Biotechnology, Maharishi Markandeshwar University, Mullana-Ambala (Haryana). India.

Current Pharmaceutical Design
|November 17, 2016
PubMed
Abstract

Insights

Breast cancer, a leading cause of cancer death in women, involves the PI3K/mTOR pathway. Inhibitors targeting this pathway show promise for new breast cancer treatments.

Area of Science:

  • Oncology
  • Molecular Biology

Background:

  • Breast cancer is a major cause of cancer-related deaths in women globally.
  • Early detection and treatment remain critical challenges.
  • The phosphoinositide 3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway is frequently activated in breast cancers, driving cell growth and tumor development.

Purpose of the Study:

  • To review the role of the PI3K/mTOR pathway in breast cancer.
  • To explore inhibitors of the PI3K/mTOR pathway as potential therapeutic agents.
  • To provide insights into the structure and regulation of mTOR.

Main Methods:

  • Literature review of preclinical and clinical trials.
  • Analysis of studies on targeted therapies for breast cancer.
  • Examination of the PI3K/mTOR pathway and its inhibitors.

Main Results:

  • The PI3K/mTOR pathway is implicated in breast cancer cell growth and tumor development.
  • Inhibitors of the PI3K/mTOR pathway, including first and second-generation agents, are being investigated.
  • These inhibitors may be effective alone or in combination with other therapies.

Conclusions:

  • Targeted therapies, particularly those inhibiting the PI3K/mTOR pathway, offer potential for improved breast cancer treatment.
  • Understanding mTOR's precise role and its inhibitors is crucial for developing effective endocrine therapies.
Keywords:
PI3K/Akt/mTORbreast cancercell proliferationcytotoxicintracellulartherapy

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