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Updated: Mar 12, 2026
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
A rapid and clean synthetic approach to cyclic peptides via micro-flow peptide chain elongation and photochemical
Yuto Mifune1, Hiroyuki Nakamura1, Shinichiro Fuse1
1Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan. sfuse@res.titech.ac.jp.
Abstract:
A cyclic RGD peptide was efficiently synthesized based on micro-flow, triphosgene-mediated peptide chain elongation and micro-flow photochemical macrolactamization. Our approach enabled a rapid (amidation for peptide chain elongation <5 s, macrolactamization <5 min) and clean (only one column chromatographic separation) synthesis of a cyclic peptide.
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