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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Pulmonary Function Tests (PFTs)
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Procedure for Lung Engineering
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Lung development.

Ling Chen1, Graeme R Zosky1

  • 1School of Medicine, Faculty of Health, University of Tasmania, Hobart, Tasmania 7000, Australia. Graeme.Zosky@utas.edu.au.

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
|November 17, 2016
PubMed
Summary
This summary is machine-generated.

Maternal vitamin D deficiency is linked to offspring chronic lung disease risk. This review explores vitamin D

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Area of Science:

  • Pulmonology
  • Endocrinology
  • Public Health

Background:

  • Epidemiological studies link maternal vitamin D deficiency to increased offspring chronic lung disease risk.
  • Vitamin D and UV-induced non-vitamin D pathways may modulate immune function and lung development.
  • Lung development is an independent predictor of later-life lung function and disease risk.

Purpose of the Study:

  • To review the current understanding of the association between UV exposure, vitamin D, and lung development.
  • To evaluate the evidence for vitamin D's role in lung development and its clinical implications.

Main Methods:

  • Narrative review of existing epidemiological, in vivo, and in vitro data.
  • Synthesis of findings on the relationship between UV exposure, vitamin D, and lung development.

Main Results:

  • Evidence suggests a causal relationship between vitamin D and lung development.
  • Non-vitamin D pathways' role in this association is not yet sufficiently supported by data.
  • Recent clinical trials have yielded equivocal results, impacting enthusiasm for vitamin D interventions.

Conclusions:

  • Vitamin D plays a role in lung development, but its public health intervention impact requires further investigation.
  • More research is needed to clarify the mechanisms and clinical utility of vitamin D for lung health.