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Fragmented QRS for Risk Stratification in Patients Undergoing First Diagnostic Coronary Angiography

Mehmet Eyuboglu1, Mehmet Akif Ekinci2, Suleyman Karakoyun3

  • 1Avrupa Medicine Center, Turkey.

Arquivos Brasileiros De Cardiologia
|November 17, 2016
PubMed

Insights

Fragmented QRS (fQRS) on ECG may indicate early heart damage in patients undergoing coronary angiography. This finding could aid in risk stratification for coronary artery disease (CAD).

Area of Science:

  • Cardiology
  • Electrocardiography
  • Diagnostic Imaging

Background:

  • A significant number of patients with suspected coronary artery disease (CAD) do not have obstructive CAD confirmed by angiography.
  • Improved risk stratification strategies are needed for these patients.

Purpose of the Study:

  • To evaluate the association between fragmented QRS (fQRS) on admission electrocardiogram and the presence and severity of CAD.
  • To assess fQRS as a potential early marker of myocardial damage in patients undergoing their first coronary angiography.

Main Methods:

  • 336 patients undergoing coronary angiography for suspected CAD were enrolled.
  • Patients were categorized based on the presence or absence of fQRS on their admission ECG.
  • Coronary artery disease presence and severity (including multi-vessel disease and SYNTAX score) were compared between groups.

Main Results:

  • Fragmented QRS (fQRS) was present in 23.5% of patients.
  • While overall CAD presence did not significantly differ, fQRS was strongly associated with stenotic CAD (40.5% vs. 10.5%, p<0.001) and multi-vessel disease (25.3% vs. 5.1%, p<0.001).
  • Higher fQRS frequency was observed in patients with SYNTAX scores >22.

Conclusions:

  • Fragmented QRS (fQRS) may serve as an early indicator of myocardial damage before fibrosis or scarring develops.
  • fQRS could be a valuable tool for risk stratification in patients undergoing initial diagnostic coronary angiography for suspected CAD.
Abstract

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