Related Experiment Video
Updated: Jul 13, 2026

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
Published on: August 18, 2016
Ergotamine enhances acetylcholine-induced relaxation in various vascular segments of rabbits
E Demirel1, F C Tulunay, R K Türker
1Department of Pharmacology, Faculty of Medicine, University of Ankara, Turkey.
Abstract:
The vasodilator response to acetylcholine and-betanechol in segments of rabbit carotid, superior mesenteric and femoral arteries preconstricted with phenylephrine and with intact endothelium was enhanced when the vessels were preincubated with ergotamine but not with ergometrine for 60 min or longer. The vasodilator response to acetylcholine and its enhancement by ergotamine were completely prevented after methylene blue pretreatment or endothelium removal. These results were taken as evidence that the potentiation by ergotamine of the vasodilator response to acetylcholine is probably due to an increased production of EDRF from the vascular endothelium.
More Related Videos
08:41Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
09:47Measurement of Endothelium-Dependent Vasorelaxation in the Mouse Thoracic Aorta Using Tensometric Small Volume Chamber Myography
Published on: August 12, 2022
Related Concept Videos
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...
Direct-Acting Cholinergic Agonists: Pharmacokinetics
Direct-Acting Cholinergic Agonists: Pharmacological Actions
Direct-Acting Cholinergic Agonists: Therapeutic Uses
Indirect-Acting Cholinergic Agonists: Pharmacological Actions
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
Cholinergic Antagonists: Therapeutic Uses
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal secretions in common...