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Related Experiment Videos

Weak acids, weak bases and intracellular pH.

A Roos

    Respiration Physiology
    |April 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    This study reviews how weak acids and bases affect animal cells, highlighting membrane permeability and active proton extrusion. It examines how these factors influence intracellular pH measurements.

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    Area of Science:

    • Cellular physiology
    • Biochemistry
    • Membrane transport

    Background:

    • Classical observations on weak acid/base behavior in cells are revisited.
    • Focuses on laboratory work concerning living animal cells.

    Purpose of the Study:

    • To review laboratory findings on weak acid and base interactions with animal cells.
    • To emphasize the role of membrane permeability and active proton extrusion.
    • To discuss the impact of intracellular inhomogeneity on transmembrane distribution and pH.

    Main Methods:

    • Review of previous laboratory experiments.
    • Analysis of electrolyte behavior across cell membranes.
    • Examination of intracellular pH dynamics.

    Main Results:

    Related Experiment Videos

    • Demonstrated active H+ extrusion in response to acid loading.
    • Highlighted the importance of membrane permeability for charged species.
    • Investigated the influence of intracellular inhomogeneity on weak acid/base distribution.

    Conclusions:

    • Membrane permeability and active proton transport are critical for understanding weak acid/base behavior in cells.
    • Intracellular inhomogeneity affects transmembrane distribution and derived pH values.
    • Accurate intracellular pH assessment requires consideration of these physiological variables.