Related Experiment Video
Updated: Mar 12, 2026
Treating Clinical Depression with Repetitive Deep Transcranial Magnetic Stimulation Using the Brainsway H1-coil
Published on: October 4, 2016
Transcranial Magnetic Stimulation Modulates Resting EEG Functional Connectivity Between the Left Dorsolateral
Shinsuke Kito1, Takashi Hasegawa1, Akihiro Takamiya1
1From the Department of Psychiatry and Advanced Medical Technology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (SK); the Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan (SK, TH, YK); the Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan (TN); the Clinical Optic Imaging Section, Department of Clinical Neuroimaging, Integrative Brain Imaging Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (TN); the National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan, (KN); and the National Center of Neurology and Psychiatry, Tokyo, Japan (TH).
Abstract:
High-frequency left prefrontal repetitive transcranial magnetic stimulation (rTMS) has been shown to have efficacy in treatment-resistant depression. However, the effects of rTMS on functional connectivity are still not clear. To examine changes in functional connectivity before and after rTMS, resting EEG of 14 patients with treatment-resistant depression was recorded twice at baseline and at week 4, respectively. The EEG data were analyzed using the standardized low-resolution brain electromagnetic tomography (sLORETA). The results reveal that high-frequency left prefrontal rTMS modulates resting EEG functional connectivity between the left dorsolateral prefrontal cortex and limbic regions, including the subgenual cingulate cortex and parahippocampal gyrus.
